Neurology
A/P Martin Krause
A/Prof Martin Krause was born and raised in Germany. In 1995 he graduated from the medical school of the Ruprecht-Karls Univeristy of Heidelberg in south-western Germany, one of the oldest faculties of the world.
He completed his medical training at the University Clinics of Heidelberg. His training focused on critical care and stroke management including i.v. and i.a. thrombolysis, hypothermia, and extra- and transcranial neurovascular ultrasound under the supervision of Prof Werner Hacke, one of the leading stroke experts (http://www.klinikum.uni-heidelberg.de/index.php?id=628&L=en). Another focus of his training was on movement disorders and neurophysiology mentored by Prof Hans-Michael Meinck, best known for his research on Stiff-Person Syndrome.
Dr Krause’s scientific interests are movement disorders especially Parkinson’s disease, Dystonia, and Tremor. In 1996 he joined the research group of Prof Volker Tronnier who was one of the first stereotactic neurosurgeons in Germany who used Deep Brain Stimulation to treat chronic pain and movement disorders. This research group was one of the first to prove Deep Brain Stimulation to be an effective treatment of generalized Dystonia, a mostly inherited, progressively disabling movement disorder.
Dr Krause is a founding member of the German Parkinson Society. He participated in the German Competence Network of Parkinson’s disease (http://www.kompetenznetz-parkinson.de/englisch/englisch.html ) and was local principal investigator for three large multicentre trials, investigating the best target for Deep Brain Stimulation in Parkinson’s disease, the effect of Deep Brain Stimulation on quality of life in Parkinson’s disease and the efficacy of Deep Brain Stimulation in primary dystonia.
In 2006, he joined the Westmead Movement Disorder Research Group for a sabbatical research program investigating the effect of deep brain lesions on motor behaviour under the mentorship of Prof. John Morris and Dr. Victor Fung.
In September 2007, he joined the medical faculty of the University of Sydney (Australia) at Nepean Clinical School as Associate Professor for Neurology. Recently he is undertaking a study investigating non motor symptoms of Parkinson’s disease together with Prof Vladan Starcevic from the Nepean Department of Medical Psychology. Furthermore he is involved in a research project, together with the Children’s Hospital Westmead, investigating the effect of Deep Brain Stimulation in dystonic Cerebral Palsy.
Together with the other staff specialists and disciplines of the Nepean Hospital a Neurology teaching curriculum was developed for year two medical students including two lectures on clinical examination and two bedside tutorials per week. Year three medical students and basic trainees have the opportunity to participate in a general neurology, neurophysiology, and stroke outpatient clinics as well as ward rounds and get experience in neurophysiology and neurovascular ultrasound.
- Research Interests
- Invasive treatment Parkinson’s disease
- Treatment of primary and secondary Dystonia
- Behaviour Neurology
- Higher visual deficits after epilepsy surgery
Selected Publications
- Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial. Mov Disord. 2008 Jan;23(1):131-4.
- Diffusion weighted MRI in the early phase after electroconvulsive therapy. Neurol Res. 2007 Apr;29(3):256-9.
- Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats. Parkinsonism Relat Disord. 2007 Dec;13(8):524-7.
- Gait analysis in patients with advanced Parkinson disease: different or additive effects on gait induced by levodopa and chronic STN stimulation. J Neural Transm. 2006 Feb;113(2):163-73.
- Pallidal deep-brain stimulation in primary generalized or segmental dystonia. N Engl J Med. 2006 Nov 9;355(19):1978-90.
- Long-term benefit to pallidal deep brain stimulation in a case of dystonia secondary to pantothenate kinase-associated neurodegeneration. Mov Disord. 2006 Dec;21(12):2255-7.
- A randomized trial of deep-brain stimulation for Parkinson's disease. N Engl J Med. 2006 Aug 31;355(9):896-908.
- Facial expression recognition and subthalamic nucleus stimulation. J Neurol Neurosurg Psychiatry. 2004 Apr;75(4):648-50.
- Chronic inhibition of the subthalamic nucleus in Parkinson's disease. J Neurol Sci. 2004 Apr 15;219(1-2):119-24.
- Pallidal stimulation for dystonia. Neurosurgery. 2004 Dec;55(6):1361-70;
- Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus. Muscle Nerve. 2003 Aug;28(2):242-5.
- Subthalamic nucleus stimulation affects a frontotemporal network: a PET study. Ann Neurol. 2003 Oct;54(4):445-50.
- High frequency stimulation of the basal ganglia for the treatment of movement disorders: current status and clinical results. Minim Invasive Neurosurg. 2002 Jun;45(2):91-6.
- Deep brain stimulation for the treatment of Parkinson's disease: subthalamic nucleus versus globus pallidus internus. J Neurol Neurosurg Psychiatry. 2001 Apr;70(4):464-70.
- Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. N Engl J Med. 2001 Sep 27;345(13):956-63.
- Ergebnisse der STN-Stimulation im Vergleich mit anderen stereotaktischen Verfahren. Act Neurol 2000;27 (Supp 1):9-15.
- Deep Brain Stimulation for the Treatment of Movment Disorders. Neurol Psychiatr Brain Res. 1999;6:199-212.
- Rehabilitation treatment after stroke. An assessment of current status. Nervenarzt. 1999 Apr;70(4):322-9.
- Association of cervical artery dissection with recent infection. Arch Neurol. 1999 Jul;56(7):851-6.
- Is the medial globus pallidus a site for stimulation or lesioning in the treatment of Parkinson's disease? Stereotact Funct Neurosurg. 1997;69(1-4 Pt 2):62-8.
- Diagnostic accuracy in remote expert consultation using standard video-conference technology. Eur Radiol. 1996;6(6):932-8.